Searching Multiple Drug Pipeline Files Simultaneously Using Chemical Structures MEDLINE® MeSH® Changes for 2006 Martindale Reloaded with New and Updated Information Expand and Enhanced Derwent World Patents Index® (DWPISM) World Textiles Now Updating Weekly Hot Topics from Thomson Scientific R&D Prospects Did You Know... Announcements Free Practice Search Techniques Call for Contributors

CSS Databases on Dialog Databases on Dialog now available for chemical structure searching include: Beilstein Facts (File 390) Derwent Chemistry Resource (File 355)** IMS Patent Focus (File 447,947)** IMS R&D Focus (File 445,955) Index Chemicus™ (File 302)** Pharmaprojects (File 128,928)** Prous Science Drug Data Report (File 452)** Prous Science Drugs of the Future (File 453) **Chemical structure images may be used to create Alerts in these databases.

What's New in MeSH®: Qualifier Changes for 2007 MeSH The National Library of Medicine has undertaken a review of existing topical qualifiers within the MeSH® vocabulary. The proposed changes retain familiar broad groups, and terms from the existing qualifiers will be retained. The goal is to insure that qualifiers met the criteria of Understandability, Reproducibility and Usability (URU). A background paper outlining the rationale for the proposed changes is available. To comment on the proposed changes, click here.

ONTAP® DWPI with Enhanced Data (File 280) In anticipation of the enhanced and expanded Derwent World Patents Index (Files 350,351,352), try searching ONTAP Derwent World Patents Index (DWPI) (File 280), the training version of DWPI. File 280 has been completely updated with patents in the new enhanced format (1985–2006). This "preview" database is available free of DialUnit, Connect Time and Output charges. Use it to explore the many new features and added data in DWPI. BEGIN 280 while logged on to Dialog. Sample searches are available for you to try. It's your chance to "check it out" for data from 1985–2006.

Here's how to find the R&D pipeline summary table for Bristol-Myers Squibb on Dialog: EXPAND to find the company name (CO=) and SELECT the section heading (SE=) for R&D pipeline table:

?b 449
?e co=bristol-myers squibb
?s e3
?s se=r&d pipeline table
?s e3
?s s1 and s2
?t s3/9/1

The table contains the compound name, laboratory code, therapeutic class and phase of development for the company's pipeline drugs.

Barbara Zimmerman
Knowledge Center

Dear Colleague

This issue of the Dialog Pharma/Biotech News e-newsletter brings you more information about chemical structure searching (CSS), reloaded MEDLINE on Dialog and Martindale on DataStar, as well as search techniques and "hot topics" in the pharmaceutical industry.

For those of you who search pharmaceutical patents, find out about the many new enhancements coming soon to Derwent World Patents Index. You can preview the new data and features on Dialog in the ONTAP DWPI (File 280). Consult the new Web page dedicated to DWPI to learn more.

Finally, keep sending us your suggestions for articles you would like to see featured in the newsletter.

Bonnie Snow, Director
Pharmaceutical Markets

Searching Multiple Drug Pipeline Files Simultaneously Using Chemical Structures

Researchers who want to save time and ensure the completeness of their chemical structure searches will find a unique feature in DialogLink 5 that meets their needs. Using DialogLink 5, you can conduct a chemical structure search in multiple drug pipeline files simultaneously.

DialogLink 5 Capabilities
Simultaneous chemical searching across multiple drug pipeline files saves you time and money by offering a single, comprehensive search of relevant, drug pipeline databases, making it easier than ever to identify potentially competitive compounds earlier in the development process. This unique capability also minimizes the risk that you will miss a critical piece of information when searching for chemical compounds.

Chemical structure searching features on DialogLink 5 also include substructure highlighting in retrieved records, as well as the ability to edit retrieved structures. It also lets you use any chemical structure drawing software that can create an industry standard MDL MOL file to generate the structure query for a Dialog chemical structure search.

With DialogLink 5, you can set up Alerts by chemical structure in some databases to scan newly added research and automatically pinpoint targeted chemical structures. Dialog Alerts generate automatic e-mail notifications when new content is added that matches your search strategy to provide current awareness of topics you specify.

Find out more about DialogLink 5.

MEDLINE® MeSH® Changes for 2006

MEDLINE® (File 154,155/ MEDL, MEZZ) on Dialog and DataStar have been reloaded. MEDLINE is reloaded every year because the National Library of Medicine (NLM) re-indexes relevant documents from the whole database with changed medical terms. For 2006, 993 new Medical Subject Headings (MeSH) were added, 188 headings were replaced with more up-to-date terminology and 50 headings were deleted.

For example, influenza in birds or bird flu is of major concern worldwide. MEDLINE has changed some of its MeSH vocabulary related to this topic for 2006. "Influenza" is now referred to as "Influenza, Humans" and "Influenza, Avian" has been renamed: "Influenza in Birds." Eight new influenza descriptors include:

• Influenza A Virus, H1N1 Subtype
• Influenza A Virus, H2N2 Subtype
• Influenza A Virus, H3N2 Subtype
• Influenza A Virus, H3N8 Subtype
• Influenza A Virus, H5N1 Subtype
• Influenza A Virus, H5N2 Subtype
• Influenza A Virus, H7N7 Subtype
• Influenza A Virus, H9N2 Subtype

Martindale Reloaded with New and Updated Information

Martindale: The Complete Drug Reference (MART) has been reloaded with new and updated information. Some of the changes include:

• Chapters and Chapter Sections including Antidementia Drugs, Antidepressants, Urological Drugs and others have been revalidated and updated
• New monographs cover Cystitis, Kinetin, Lutein, Liarozole and more
• Selective updates on diseases and drugs contain new, revalidated and updated information
• Preparations data are now available for Venezuela and updated for other countries like Greece and Chile

For more information check the MART DataSheet or the BASE database: BASE-MART.

Expanded and Enhanced Derwent World Patents Index® (DWPI^SM)

Derwent World Patents Index® (DWPI^SM) (Files 350, 351, 352) is being reloaded with expanded content and many enhancements designed to save you time and effort. In addition to the distilled expert analysis reflected in DWPI enhanced titles and abstracts, now available are original patent filing details, multiple patent images, easy cut-and-paste patent family data, and much more.

Three areas of enhancement include new content such as details from original patent filings in different countries or granting authorities and multiple images; new indexing for inventor name and country codes; and new display options.

World Textiles Now Updating Weekly

World Textiles™ (File 67) is now updating weekly. In addition to being a leading source on textiles, technology and applications as reported in technical, scientific, economic and commercial journals and statistical publications, World Textiles covers subjects such as protective materials, dressings, medical equipment, medical clothing, textiles finishing and washing, etc. World Textiles also includes unique coverage of the related patents and patent applications from the USPTO, European and British patent offices.

Hot Topics from Thomson Scientific

Every two months, Thomson Scientific specialists identify emerging and fast-moving "Research Fronts"—areas of scientific research that gain particular attention, and "Hot" and "Fast-Breaking Papers"—individual papers that achieve a rate of citation that is markedly higher than papers of comparable type and age.

Thomson Scientific ESI Special Topics Web site is updated with new analyses and information each month—including interviews with noteworthy authors and insight into up-and-coming research trends. One of the latest topics considered is the potential to diagnose Alzheimer's disease. Read the interview of William Klein on the topic of his paper.

For more information on other topics, check the ESI Special Topics Web site.

R&D Prospects

With headlines in the news about avian flu, SARS, the threat of bioterrorism and other adult influenzas, large pharmaceutical companies have increased their interest in the vaccine market.

Read the entire article about the rising interest in vaccines from large pharmaceutical companies, including a look at the obstacles for vaccine manufacturers and the response to avian flu.

Call for Contributors

Participate in knowledge sharing with your colleagues interested in pharmaceutical-related topics. Share your story suggestions with us at support.dialog.com/enewsletters/contribute/.