Dear Colleague

Recent Dialog Pharmaceutical Forums held in numerous locations presented sessions on how to get the most from the pharmaceutical databases on Dialog and DataStar. Attendees were very interested in pharmacovigilance and chemical structure searching in the Dialog pipeline databases, two of the topics covered in the Forums. More Pharmaceutical Forums are planned for 2007. Dates and locations will be announced in an upcoming issue of Pharma/Biotech News.

In this issue we highlight some of the changes in the Adis and IMS drug pipeline files. See how new fields added to the databases will allow you to structure your searches and Alerts more specifically and gain the latest information about ongoing clinical trials.

Bonnie Snow, Director
Pharmaceutical Markets

Adis Clinical Trials Insight Reloaded with New Fields

Adis Clinical Trails Insight (File 173, 373/ACTI) has been reloaded with new fields to let you pinpoint exactly the information you need and track the latest developments in ongoing clinical trials. New fields in the file include: Drug Name, References, ATC WHO Codes, EphMRA codes, creation date, study identifiers, Adis R&D Insight (File 107/ADRD) links, meeting name, study name, patient minimum and maximum age/units, planned number of patients, Study status, Latest update date.

Comprehensive Information about Ongoing Trials
Updated weekly, Adis Clinical Trials Insight is the only place to retrieve data about ongoing trials, as well as presented and published trial data in a single searchable database. Set up Alerts to help identify and assess the growing universe of clinical trial studies for new drugs and therapies. File 173 also contains full assessments of important trials from 1990 to the present and includes coverage of more than 40,000 published and ongoing trials per year.

IMS R&D Focus: Added Content, Improved Functionality

IMS R&D Focus (IPUR) on DataStar has been reloaded resulting in more content and improved functionality. Additional data enable you to identify important concepts in drug research such as:

• Whether a drug is in active development
• Whether the document has undergone a major change
• Whether the major change is a development phase change
• Route of Administration

New fields enable you to set up your Alert strategies to focus specifically on areas like document and development phase changes or route of administration.

Publisher Records in MEDLINE® on DataStar

Publisher records are now available in MEDLINE (MEDL, MEZZ, MEIP) on DataStar. There are several differences between these records and those in MEDLINE:

• Foreign language articles often do not have an English-language title
• Some records are out of MEDLINE’s usual content scope
• Journal titles are only available in abbreviated form

Publisher records are handled in the same way as other “In Process” records and will be overwritten when they appear in MEDLINE later. You can retrieve Publisher records on DataStar with PUBLISHER=YES or PUBLISHER.AN. and identify them by the presence of the word “Publisher” in the Accession Number field.

Elsevier Science Introduces New Bibliographic Data Elements

Elsevier has introduced some new publication types and associated features in EMBASE (File 72,73/EMED,EMZZ), Elsevier BioBase (File 71/ELBI) and EMCare (File 45/EMCA). The new features include:

• Two new publication types: "Trade Journal" and "Proceeding"’
• Titles of journal issues that have their own distinct title
• Names of editors of specific issues
• ISBNs of journals that are book series; both 10- and 13-digit ISBNs are provided where available

Comprehensive Drug Monitoring Using Chemical Structures in the Pipeline Databases

For a comprehensive understanding of the current drug research environment, it is vital to consult multiple databases. A study by Diane Q. Webb and John A. Willmore of BizInt Solutions Inc. shows that searching only one pipeline database will generally retrieve only about 40 percent of the unique compounds in the pipelines of all drug companies.

Read the article by Bob Stewart, entitled "Comprehensive Drug Monitoring Through Multi-File Chemical Structure Searching," to learn more about this important topic.

In his article, Stewart illustrates that only by searching multiple pipelines and using chemical structure searching can researchers be truly assured of a comprehensive search, thereby protecting investments made in current research.

Call for Contributors

Participate in knowledge sharing with your colleagues interested in pharmaceutical-related topics. Share your story suggestions with us at support.dialog.com/enewsletters/contribute/.