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Use the MAP Command to Begin a Basic Toxicology Search?
TOPIC: Toxicological information is important in a wide range of areas: industrial hygiene, criminalistics and forensics, poison control, substance abuse research, laboratory safety, to name but a few. Chapman and Hall Chemical Database (File 303), The Merck Index OnlineSM (File 304) and Registry of Toxic Effects of Chemical Substances (RTECS®) provide information on synonyms of chemical names.
These files should be considered to be the central files for locating synonyms and CAS® Registry Numbers (which uniquely identify chemical entities) for searches in other files.
Peer reviewed articles will appear in BIOSIS Previews® (File 5), BIOSIS® Toxicology (File 157), EMBASE® (File 73), MEDLINE® (File 155), PASCAL (File 144), SciSearch®—A Cited Reference Science Database (File 34,434) and other files.
See the related How Do I Find Basic Toxicology Information In Chemical Directory Files? for more information about toxicity of a chemical.
This example shows the use of the MAP command in RTECS to create a temporary SearchSave of synonyms of a chemical, and a method for using the SearchSave to find articles about the chemical in ToxFile® (File 156).
COMMAND SUMMARY
BEGIN 336
EXPAND NA=CUMENE
SELECT APPROPRIATE "E" REFERENCE NUMBER
MAP SYRN T
RECALL TD481
BEGIN 156
EXS
SELECT S1 AND (SKIN OR DERM?)
SELECT S2 AND PY>2005
HOW TO...

1. BEGIN File 336 to search RTECS.
2. EXPAND the chemical name on the Chemical Name (NA=) field.
3. SELECT the appropriate "E" Reference number. |

? b336
File 336:RTECS 2012/Q3
Portions (c) Copyright 2012, U.S. Government. Rights Res
Set Items Description
--- ----- -----------
? e na=cumene
Ref Items Index-term
E1 1 NA=CUMEENHYDROPEROXYDE
E2 1 NA=CUMELON
E3 1 *NA=CUMENE
E4 1 NA=CUMENE ALDEHYDE
E5 1 NA=CUMENE HYDROPEROXIDE
E6 1 NA=CUMENE HYDROPEROXIDE MIXED WITH BETA-NAPHTHYLA
E7 1 NA=CUMENE PEROXIDE
E8 1 NA=CUMENE, ALPHA,BETA-EPOXY-
E9 1 NA=CUMENE, P-METHYL-
E10 1 NA=CUMENYL HYDROPEROXIDE
E11 1 NA=CUMERTILIN SODIUM
E12 1 NA=CUMIC ACID
E13 1 NA=CUMIC ALCOHOL
E50 1 NA=CUPANIA LESSERTIANA CAMBESS, EXTRACT
Enter P or PAGE for more
? s e3
S1 1 NA='CUMENE' |

4. Use the MAP command to create a temporary SearchSave, which contains the synonyms (SY) and CAS Registry Number (RN).
This example shows the creation of temporary SearchSave #TD481.
5. RECALL the temporary SearchSave number to view the terms saved. |

? map syrn t
Temp SearchSave "TD481" stored
3 Select Statements, 17 Search Term(s)
SearchSave TD481
1 SearchSave(s), 17 Search Term(s)
? recall td481
Name: TD481
Modified: 25sep12
Line Commands:
----- ---------
1. S 1()METHYLETHYL()BENZENE + BENZENE()1()METHYLETHYL +
BENZENE()ISOPROPYL + CUMEEN + CUMENE + CUMOL + ISOPROPILBENZENE +
ISOPROPYL()BENZENE + ISOPROPYL()BENZOL + ISOPROPYLBENZEEN +
ISOPROPYLBENZOL + PROPANE()2()PHENYL
2. S RCRA()WASTE()NUMBER()U055 + 2()FENILPROPANO + 2()FENYL()PROPAAN +
2()PHENYLPROPANE + RN=98-82-8
3. S S1:S2
|

6. BEGIN File 156 to search ToxFile.
7. EXECUTE the temporary SearchSave to create search sets of all the hits on cumene or its synonyms in ToxFile.
Note that Cumene appears along with the other synonyms and the CAS Registry Number saved with the MAP command.
If the search statement exceeds 240 characters the system will automatically create an additional SELECT statement. This EXECUTE STEPS created two SELECT statements, plus S3, which ORed S1 and S2 together.
Note: partial display shown. |

? exs
Processing
Executing TD481
1337890 1
749 METHYLETHYL
20274 BENZENE
19 1(W)METHYLETHYL(W)BENZENE
20274 BENZENE
1337890 1
749 METHYLETHYL
2 BENZENE(W)1(W)METHYLETHYL
20274 BENZENE
4640 ISOPROPYL
2 BENZENE(W)ISOPROPYL
0 CUMEEN
1203 CUMENE
7 CUMOL
0 ISOPROPILBENZENE
4640 ISOPROPYL
20274 BENZENE
...
0 PROPANE(W)2(W)PHENYL
S1 1241 1()METHYLETHYL()BENZENE + BENZENE()1()METHYLETHYL +
BENZENE()ISOPROPYL + CUMEEN + CUMENE + CUMOL +
ISOPROPILBENZENE + ISOPROPYL()BENZENE + ISOPROPYL()BENZOL
+ ISOPROPYLBENZEEN + ISOPROPYLBENZOL + PROPANE()2()PHENYL
2425 RCRA
98275 WASTE
252634 NUMBER
0 U055
0 RCRA(W)WASTE(W)NUMBER(W)U055
1242757 2
0 FENILPROPANO
0 2(W)FENILPROPANO
1242757 2
13 FENYL
0 PROPAAN
0 2(W)FENYL(W)PROPAAN
1242757 2
39 PHENYLPROPANE
4 2(W)PHENYLPROPANE
280 RN=98-82-8
S2 283 RCRA()WASTE()NUMBER()U055 + 2()FENILPROPANO +
2()FENYL()PROPAAN + 2()PHE
S3 1353 S1:S2 |
8. Narrow your search with relevant keyword terms to create a set of primary records from research data.
9. Further narrow your set to research published after a specific year. |
? s s3 and (skin or derm?)
1353 S3
155117 SKIN
80749 DERM?
S4 108 S3 AND (SKIN OR DERM?)
? s s4 and py>2005
108 S4
831293 PY>2005
S5 6 S4 AND PY>2005 |
10. TYPE out the records from this set in Format 6, KWIC (K), to learn new information about this compound.
Note: Dialog provides free links to electronic publishers for holders of electronic journal subscriptions. See www.dialog.com/
products/ejournal/ for details.
Note: Some records have been omitted from this display. |
? t s5/6,k/1-3
Dialog eLink:
5/6,K/1
DIALOG(R)File 156: ToxFile
(c) format only 2012 Dialog. All rights reserved.
4982546 NLM Doc No: 21692810
Sensory irritation caused by two organic solvents-short-time single application and repeated occlusive test in stingers and non-stingers.
Aug 2011
Journal Name: Pub. Year: ...2011
...chemicals. Objectives. To investigate the sensory irritation induced by two organic solvents - n-octane and cumene - between two groups of volunteers, stingers and non-stingers, identified as such according to the ... ...The volunteers graded the reaction intensities by the use of a labelled magnitude scale. RESULTS: Cumene induced significantly stronger sensory irritation than octane in both the single and the repeated applications... ...less subjective irritation the more times the volunteers were exposed. The decline with time for cumene was statistically significant for the non-stingers but not for the stingers. However, no significant... (
Descriptors: *Benzene Derivatives--adverse effects--AE; *Cosmetics--adverse effects--AE; *Dermatitis, Irritant--etiology--ET; *Irritants--adverse effects--AE ; *Octanes--adverse effects--AE; *Patch Tests--methods--MT; *Skin --drug effects--DE ; Adult; Dermatitis, Irritant--diagnosis--DI; Humans; Reference Values ; Reproducibility of Results; Sensitivity and Specificity; Sensory Thresholds--drug...
Named Person:
Chemical Name: Benzene Derivatives; Cosmetics; Irritants; Octanes; octane; cumene |
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