1. BEGIN File 990 to search Dialog NewsRoom.

2. SELECT key terms using proximity connectors, such as (W), to search a phrase. Be sure to enclose synonyms in parentheses when ANDing in another term.

?b 990

File 990:NewsRoom Current Apr 01-2008/Jul 22
       (c) 2008 Dialog

      Set  Items  Description
      ---  -----  -----------
?s (pcsk1 or pcsk(w)1) and obesity
               8  PCSK1
               2  PCSK
         5607201  1
               0  PCSK(W)1
          133790  OBESITY
      S1       5  (PCSK1 OR PCSK(W)1) AND OBESITY

3. ADD another database, such as Dialog Global Reporter.

4. Enter REPEAT to execute the same search statement again, now including the second file.

5. REMOVE DUPLICATES (RD) when searching more than one database.

?add  20

SYSTEM:OS  - DIALOG OneSearch
You have   2 files in your file list.
(To see file names, coverage dates, and copyright notices, 
enter SHOW FILES.)

      Set  Items  Description
      ---  -----  -----------
Added File(s): 20
Previous sets have been retained; enter DISPLAY SETS to view them.

?repeat
              10  PCSK1
               5  PCSK
        21798937  1
               0  PCSK(W)1
          216542  OBESITY
      S1       7  (PCSK1 OR PCSK(W)1) AND OBESITY

?rd
      S2       6  RD  (unique items)

6. TYPE records in Formats 8 and K (KWIC), which together give the title, journal name, publication date, word count, indexing and keywords in context in 30-word windows. Notice the amount of information given with Keywords in Context (KWIC).

Note: Portions of the records are omitted from this display.

To select the appropriate record number, look at the range of records in the TYPE command (e.g., 2/8,K/2).

Note: Some records have been omitted from this display.

?t s2/8,k/all

2/8,K/1 (Item 1 from file: 990)
DIALOG(R)File 990: NewsRoom Current
(c) 2008 Dialog. All rights reserved.

1617547032   18331FXR
TWO STUDIES IDENTIFY GENETIC INFLUENCES UNDERLYING OBESITY: By
Rachael Dobson

BioNews
Sunday , July 20, 2008
Word Count: 603

Company Names: BAYLOR COLLEGE OF MEDICINE; EDITIONS DES DERNIERES
NOUVELLES D'ALSACE SA
Dialog Update Date: 20080722; 08:23:57 EST
Journal Subject: Healthcare
TWO STUDIES IDENTIFY GENETIC INFLUENCES UNDERLYING OBESITY: By
Rachael Dobson

Text:
Researchers at Imperial College London have identified a genetic
link to obesity. Comparing the DNA of over 13,000 obese individuals
to the DNA of non-obese control subjects, they identified three single nucleotide polymorphisms (SNPs) in the PCSK1 gene that were
associated with obesity.

The SNPs - single 'letter' mutations in the DNA code of the PCSK1
gene - were more common in individuals who were obese than in the 
normal weight controls. The three SNPs identified in the study were 
also associated with childhood obesity, as well as less extreme 
weight gain.

The PCSK1 gene is an enzyme that converts inactive
appetite-controlling hormones into their active form. PCSK1 also
controls the hormones insulin and glucagon, which regulate the 
metabolism of sugars and carbohydrates...

. . . .
...the first time that we have found a strong link between common 
mutations and common obesity in the PCSK1 gene', said Professor
Froguel. 'We all react differently to an environment that is 
becoming more...

- The Daily Telegraph 7/7/2008 'Famished gene is found and could 
help tackle obesity'

- The Daily Telegraph:
http://www.telegraph.co.uk/earth/main.jhtml?xml=/earth/2008/07/07/
scigene107 .xml
- Associated Press 6/7/2008 'Hardwired for fat: scientists identify
obesity gene'

. . . .

  2/8,K/2 (Item 2 from file: 990) 
DIALOG(R)File 990: NewsRoom Current
        (c) 2008 Dialog. All rights reserved.

1611560151   182R1URQ 
        
Scientists identify common genetic mutations linked to obesity in 
Europeans 
Pharma Company Insight 
Tuesday , July 8, 2008 
Word Count: 253 

Company Names: IMPERIAL COLLEGE LONDON 
Dialog Update Date: 20080708; 18:11:24 EST 
Industry Names: SCIENCE; ENGINEERING; BIOTECHNOLOGY; PHARMACEUTICAL  
INDUSTRY; PREVENTIVE MEDICINE; NUTRITION AND DIETETICS; HEALTH AND 
FITNESS 
Journal Subject: Pharmaceuticals & Biotechnology;Business Management 
Scientists identify common genetic mutations linked to obesity in 
Europeans 

        Text:
...10.1038/ng.177), the mutations have a significant effect on the 
risk of common obesity.

The PCSK1 gene is known to code for the proconvertase enzyme, which
is responsible for producing fully-functioning versions of hormones 
such as insulin, glucagon and melanocortin. Changes in the PCSK1 
gene cause relatively minor abnormalities in proconvertase, but 
the effect on the hormones is significant...

To assess the contribution of PCSK1 to polygenic obesity
risk, the team genotyped tag SNPs in a total of 13,659 individuals 
of European...

. . . .

7. TYPE selected records in Format 7, for the full record except indexing.

Note: Part of this record is omitted from the display.

This article includes references and URLs to sources.

?type s2/7/1
  
  2/7/1 (Item 1 from file: 990) 
  DIALOG(R)File 990: NewsRoom Current
  (c) 2008 Dialog. All rights reserved.
  
  1617547032  18331FXR 
  TWO STUDIES IDENTIFY GENETIC INFLUENCES UNDERLYING OBESITY: 
By Rachael Dobson
  BioNews , n 467
  Sunday , July 20, 2008 
  Word Count: 603 
  
  Text:
Researchers at Imperial College London have identified a genetic 
link to obesity. Comparing the DNA of over 13,000 obese individuals 
to the DNA of non-obese control subjects, they identified three 
single nucleotide polymorphisms (SNPs) in the PCSK1 gene that 
were associated with obesity.

The SNPs - single 'letter' mutations in the DNA code of the PCSK1
gene - were more common in individuals who were obese than in the 
normal weight controls. The three SNPs identified in the study were 
also associated with childhood obesity, as well as less extreme 
weight gain. The PCSK1 gene is an enzyme that converts inactive
appetite-controlling hormones into their active form. PCSK1 also
controls the hormones insulin and glucagon, which regulate the 
metabolism of sugars and carbohydrates in the body. Professor 
Philippe Froguel, who led the study, suggested that the SNPs may 
be responsible for altering the PCSK1 gene to a more active form, 
which could alter appetite levels in the body.

Most genes associated with obesity have been linked to rare genetic
conditions that lead to extreme weight gain, and these genetic 
mutations are not common in the general population. 'This is the 
first time that we have found a strong link between common 
mutations and common obesity in the PCSK1 gene', said Professor 
Froguel. 'We all react differently to an environment that is 
becoming more and more similar, and the reason we react differently 
is in part genetic in origin'.

In another study, US researchers at Baylor College of Medicine in 
Houston, Texas, showed that the
(…)

- The Daily Telegraph 7/7/2008 'Famished gene is found and could 
help tackle obesity'
- The Daily Telegraph:
http://www.telegraph.co.uk/earth/main.jhtml?xml=/earth/2008/07/07/
scigene107 .xml
- Associated Press 6/7/2008 'Hardwired for fat: scientists identify
  obesity gene'
- Associated Press:
http://afp.google.com/article/ALeqM5jSRiOUpbpkYmolsj1QqjS-T130Fg
- BBC News Online 16/7/2008 'Gene tags 'fuel obesity epidemic''
- BBC News Online:
http://news.bbc.co.uk/1/hi/health/7508034.stm
- The Daily Telegraph 15/7/2008 'Obesity will increase with each
generation, medical experts warn'
- The Daily Telegraph:
http://www.telegraph.co.uk/news/worldnews/northamerica/usa/2302685/
Obesity-will-increase-with-each-generation%2C-medical-experts-
warn.html

Copyright (c) 2008 BioNews