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Locate Clinical Trials Being Conducted in a Particular Year on a Specific Drug?
TOPIC: In this example, using four biomedical databases—MEDLINE® (File 154), EMBASE® (File 72), BIOSIS Previews® (File 55) and SciSearch®: A Cited Reference Database (File 34)—you want to find recent clinical trials for the drug Infliximab, a drug used to treat rheumatoid arthritis.
All four databases are central to biomedical research; however, as the example shows, they are searched differently. Both MEDLINE and EMBASE have their own thesaurus to help in locating search terms. In these two databases, you will use the EXPLODE command (!) to select all narrower terms for clinical trials quickly and easily. In BIOSIS and SciSearch, you want to use as many keyword synonyms as possible to conduct the search.
COMMAND SUMMARY
BEGIN 154,72,55,34
SELECT INFLIXIMAB/TI,DE AND DT=(CLINICAL? OR MULTICENTER? OR RANDOMIZED? OR META? OR CONTROLLED?) OR CLINICAL TRIALS! FROM 154
SELECT INFLIXIMAB(L)CT OR (INFLIXIMAB/TI,DE AND CLINICAL TRIAL!) FROM 72
SELECT INFLIXIMAB/TI,DE,ID AND ((CLINICAL OR RANDOMI? OR CONTROLLED)(1W)(TRIAL OR STUDY OR STUDIES) OR MULTICENTER OR META()ANALYS? OR PHASE(W) (I OR II OR III OR 1 OR 2 OR 3)) FROM 55,34
SELECT S1 OR S2 OR S3
SELECT S4/2005
RD
TYPE S6/6/1-2 FROM EACH
TYPE S6/9/1
HOW TO...
1. BEGIN 154, 72, 55, 34 to search key biomedical databases.
2. Create a search statement for MEDLINE using:
- Document types (DT=)
- Suffixes for title (/TI) and descriptors (/DE)
- EXPLODE (!) to retrieve all phases of clinical trials
- FROM 154 to search just MEDLINE
3. Create a search statement for EMBASE using:
- (L) connector to connect heading and subheading for clinical trial (CT)
- Suffixes for title (/TI) and descriptors (/DE)
- EXPLODE (!) to retrieve all phases of clinical trials
- FROM 72 to search only EMBASE
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4. Create a search statement for BIOSIS and SciSearch using:
- Suffixes for title (/TI), descriptors (/DE) and identifiers (ID)
- Synonyms for clinical trials, remembering to put ORed terms in parentheses
- FROM 55,34 to search both BIOSIS and SciSearch
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5. Combine the three sets using OR and narrow to the current year.
6. REMOVE DUPLICATES (RD) when searching more than one database.
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7. TYPE titles using Format 6 and FROM EACH to identify records in each database to view in more detail.
You can review toxicology literature on this drug or display all or parts of the record.
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8. For complete records TYPE in Format 9 or click the drop-down Links box.
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RELATED HOW DO I...? SOLUTIONS
NEED HELP?
Contact the Dialog Knowledge Center
Within North America 1 800 3 DIALOG (334 2564)
Outside North America 00 800 33 DIALOG (33 34 2564)
Web Form www.dialog.com/contacts/webform
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