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Find Reported Adverse Effects of a Particular Drug?
TOPIC: In this example, using three biomedical databases MEDLINE® (File 154), Embase® (File 72) and Embase® Alert (File 172), you want to find adverse effects reported for the anti-anxiety drug Paxil, especially as it relates to hair loss.
MEDLINE® is a major source of biomedical literature and Embase® contains biomedical information with a focus on drug literature. Both files provide excellent indexing — thesauri — which guide you to the right terms with a simple EXPAND command. Because MEDLINE and Embase use different indexing (NLM Medical Subject Headings MeSH® and Emtree respectively) it is best to EXPAND, browse terms and SELECT terms FROM EACH file. You can select specific adverse effects indexing from the EXPANDs or select the drug name and combine it with the two-letter codes for the adverse effects you want. The (L) connector links the heading (paroxetine) to subheadings (adverse effects) found in the descriptor field.
It is important to pick up new documents quickly. Embase Alert and "In Process" records in MEDLINE are not indexed, so in order to do a comprehensive search, a free-text version of the indexed strategy must also be part of a comprehensive search strategy.
COMMAND SUMMARY
BEGIN 154,72,172
EXPAND PAROXETINE FROM 154
SELECT E3 (L) (AE OR TO OR CT OR PO)FROM 154
EXPAND PAROXETINE FROM 72
SELECT E3 (L) (AE OR TO OR IT) FROM 72
SELECT PAROXETINE (10N)(ADVERSE OR SIDE)(3N)(REACTION OR EFFECT? ?) OR
PAROXETINE (10N)(CONTRAINDICATION? OR POISON? OR TOXIC?)
SELECT S1:S3
SELECT S4 AND (HAIR()LOSS OR ALOPECIA)
RD
TYPE S6/6/1-2 FROM EACH
TYPE S6/9/2
HOW TO...
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1. After BEGINning in MEDLINE, Embase and Embase Alert, EXPAND using the generic name for Paxil FROM MEDLINE. Browse the allowable subheadings.
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?BEGIN 154,72, 172
SYSTEM:OS - DIALOG OneSearch
File 154:MEDLINE(R) 1990-2012/Nov 07
(c) format only 2012 Dialog
File 72:EMBASE 1993-2012/Nov 08
(c) 2012 Elsevier B.V.
File 172:EMBASE Alert 2012/Nov 07
(c) 2012 Elsevier B.V.
Set Items Description
--- ----- -----------
? EXPAND PAROXETINE FROM 154
Ref Items RT Index-term
E1 40 PAROXETIN
E2 27 PAROXETINA
E3 4677 9 *PAROXETINE
E4 419 PAROXETINE --ADMINISTRATION AND DOSAGE --AD
E5 960 PAROXETINE --ADVERSE EFFECTS --AE
E6 9 PAROXETINE --ANALOGS AND DERIVATIVES --AA
E7 40 PAROXETINE --ANALYSIS --AN
E8 9 PAROXETINE --ANTAGONISTS AND INHIBITORS --AI
E9 164 PAROXETINE --BLOOD --BL
E10 1 PAROXETINE --CEREBROSPINAL FLUID --CF
E11 19 PAROXETINE --CHEMICAL SYNTHESIS --CS
E12 48 PAROXETINE --CHEMISTRY --CH
...
Enter P or PAGE for more
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2. SELECT the appropriate E number (E3) FROM MEDLINE and use the (L) operator to link headings with the subheadings for adverse effects (AE), toxicity (TO), contraindications (CT) and poisoning (PO).
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? SELECT E3 (L) (AE OR TO OR CT OR PO)FROM 154
3170 PAROXETINE/DE
892748 AE/DE
366207 TO/DE
15849 CT/DE
26837 PO/DE
S1 1000 'PAROXETINE' (L) (AE OR TO OR CT OR PO)FROM 154
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3. EXPAND using the generic name for Paxil FROM Embase and browse the subheadings indexed for the drug.
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? EXPAND PAROXETINE FROM 72
Ref Items RT Index-term
E1 1 PAROXETIN RATIOPHARM
E2 49 PAROXETINA
E3 20703 33 *PAROXETINE
E4 4688 PAROXETINE --ADVERSE DRUG REACTION --AE
E5 3139 PAROXETINE --CLINICAL TRIAL --CT
E6 121 PAROXETINE --DRUG ADMINISTRATION --AD
E7 314 PAROXETINE --DRUG ANALYSIS --AN
E8 1831 PAROXETINE --DRUG COMBINATION --CB
E9 2557 PAROXETINE --DRUG COMPARISON --CM
E10 478 PAROXETINE --DRUG CONCENTRATION --CR
E11 111 PAROXETINE --DRUG DEVELOPMENT --DV
E12 1985 PAROXETINE --DRUG DOSE --DO
...
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4. SELECT the appropriate E number (E3) FROM Embase and use the (L) operator to link headings with the subheadings for adverse drug reaction (AE), toxicity (TO) and drug interactions (IT) FROM Embase.
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? SELECT E3 (L) (AE OR TO OR IT) FROM 72
20332 PAROXETINE/DE
778181 AE/DE
426150 TO/DE
114881 IT/DE
S2 6030 'PAROXETINE' (L) (AE OR TO OR IT) FROM 72
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5. Enter free-text terms related to adverse effects from the generic name for Paxil.
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? SELECT PAROXETINE (10N)(ADVERSE OR SIDE)(3N)(REACTION OR EFFECT? ?)
OR PAROXETINE (10N)(CONTRAINDICATION? OR POISON? OR TOXIC?)
25427 PAROXETINE
2008303 ADVERSE
1120585 SIDE
2597391 REACTION
7376667 EFFECT? ?
7849 PAROXETINE(10N)(ADVERSE OR SIDE)(3N)(REACTION OR
EFFECT? ?)
25427 PAROXETINE
81267 CONTRAINDICATION?
106457 POISON?
1151678 TOXIC?
635 PAROXETINE(10N)((CONTRAINDICATION? OR POISON?) OR
TOXIC?)
S3 8294 PAROXETINE (10N)(ADVERSE OR SIDE)(3N)(REACTION OR
EFFECT? ?) OR PAROXETINE (10N)(CONTRAINDICATION?
OR POISON? OR TOXIC?)
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6. OR the sets together using a colon for the range of S1-S3.
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? SELECT S1:S3
S4 9129 S1:S3
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7. Combine the results of S4 with concepts of hair loss or alopecia.
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? SELECT S4 AND (HAIR()LOSS OR ALOPECIA)
9129 S4
91768 HAIR
1024472 LOSS
9214 HAIR(W)LOSS
35833 ALOPECIA
S5 117 S4 AND (HAIR()LOSS OR ALOPECIA)
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8. REMOVE DUPLICATES.
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? rd
S6 113 RD (unique items)
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9. To view titles use Format 6 and type a sampling of records FROM EACH database.
Note: some records omitted from the display.
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? T S6/6/1-2 FROM EACH
Dialog eLink:
6/6/1 (Item 1 from file: 154)
DIALOG(R)File 154: MEDLINE(R)
(c) format only 2012 Dialog. All rights reserved.
14207756 PMID: 10883182
[Alopecia due to Seroxat therapy].
Apr 2 2000
Dialog eLink: 
6/6/2 (Item 2 from file: 154)
DIALOG(R)File 154: MEDLINE(R)
(c) format only 2012 Dialog. All rights reserved.
13926960 PMID: 10442258
Hair loss associated with paroxetine treatment: a case report.
Jul-Aug 1999
Dialog eLink:
6/6/3 (Item 1 from file: 72)
DIALOG(R)File 72: EMBASE
(c) 2012 Elsevier B.V. All rights reserved.
0085841807 EMBASE/MEDLINE No: 2012304511
From the field of play to the field of combat: A review of the
pharmacological management of concussion
Publication Date: June 1, 2012
....
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10. Using Format 9, TYPE the desired complete record(s).
Indexing at the bottom of the record may provide insight on additional search terms or directions to take. |
? T S6/9/2
Dialog eLink:
6/9/2 (Item 2 from file: 154)
DIALOG(R)File 154: MEDLINE(R)
(c) format only 2012 Dialog. All rights reserved.
13926960 PMID: 10442258
Hair loss associated with paroxetine treatment: a case report.
Zalsman G; Sever J; Munitz H
Geha Psychiatric Hospital, Petah Tiqva, Israel.
Clinical neuropharmacology ( UNITED STATES ) Jul-Aug 1999 , 22 (4) p246-7 , ISSN: 0362-5664--Print 0362-5664--Linking Journal Code: 7607910
Publishing Model Print
Document type: Case Reports; Journal Article
Languages: ENGLISH
Main Citation Owner: NLM
Record type: MEDLINE; Completed
Subfile: INDEX MEDICUS; Toxbib
Alopecia and hair loss are rare side effects of psychotropic drugs. There are a few case reports on hair loss associated with tricyclic antidepressants and serotonin selective reuptake inhibitors (SSRIs), but none deal specifically with paroxetine. We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment. Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine. Further investigation is needed to determine the scope of this troubling side effect.
Tags: Female
Descriptors: *Alopecia--chemically induced--CI; *Antidepressive Agents, Second-Generation--adverse effects--AE; *Paroxetine-- adverse effects--AE ; Adult; Depression--drug therapy--DT; Humans
CAS Registry No.: 0 (Antidepressive Agents, Second-Generation); 61869-08-7 (Paroxetine)
Record Date Created: 19990928
Record Date Completed: 19990928
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