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Locate Peer-reviewed Chemical Literature for a Specific Drug for a Particular Indication?
TOPIC: In this example, you want to find peer-reviewed literature for the drug Lipitor, a cholesterol-lowering drug using Embase® (File 72. 73) to find the CAS® Registry Number for Lipitor.
The CAS Registry Number is a unique number given to chemical substances. You will SELECT and SAVE the CAS Registry Number(s) and then you will search the biomedical literature, including Embase using the saved CAS Registry Numbers.
Biomedical databases such as MEDLINE® (File 154, 155) and BIOSIS Previews®(File 5, 55) are examples of files that contain literature related to research and development of drugs and have a CAS Registry Number field (RN=).
COMMAND SUMMARY
BEGIN 72
EXPAND (LIPITOR)
EXPAND R2
SELECT R20 OR R21
SAVE TEMP LIPITOR
B 154,55,72
EXS
SELECT (ATORVASTATIN OR LIPITOR) FROM 154
SELECT S1 AND S2
SELECT S3 AND CHOLESTEROL/TI,DE
S S4/2012
RD
TYPE S6/6/1-2 FROM EACH
TYPE S6/7/1 FROM 72
HOW TO...
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1. BEGIN 72, a database containing information on chemical substances.
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? b72
File 72:EMBASE 1993-2012/Sep 25
(c) 2012 Elsevier B.V.
*File 72: Embase has been enhanced with Conference Abstract records.
Please see HELP NEWS072 for information.
Set Items Description
--- ----- ----------- |
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2. EXPAND the drug name using parentheses. Embase points to the preferred term in Reference number R2, atorvastatin, with the letter U in the Type column.
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? e (lipitor)
Ref Items Type RT Index-term
R1 1576 1 *LIPITOR
R2 21193 U 20 ATORVASTATIN
Enter P or PAGE for more |
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3. EXPAND the appropriate R number (R2) to see the synonyms and CAS Registry Number(s) for atorvastatin.
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? e r2
Ref Items Type RT Index-term
R1 20990 20 *ATORVASTATIN
R2 45104 B 43 HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INH
R3 3 S 1 ATORLIP
R4 1 S 1 ATORVASTATIN CALCIUM
R5 0 S 1 ATOVAROL
R6 29 S 1 CI 981
R7 0 S 1 CI981
R8 0 S 1 GLUSTAR
R9 0 S 1 LIPIBEC
R10 1566 S 1 LIPITOR
R11 0 S 1 LOWLIPEN
R12 180 S 1 SORTIS
R13 5 S 1 STORVAS
R14 57 S 1 TAHOR
R15 10 S 1 TORVAST
R16 6 S 1 YM 548
R17 7 S 1 YM548
R18 11 S 1 ZARATOR
R19 0 S 1 2 (4 FLUOROPHENYL) BETA,DELTA DIHYDROXY 5 ISOP
R20 19364 S 1 RN=134523-00-5
R21 19364 S 1 RN=134523-03-8
Enter P or PAGE for more |
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4. SELECT the appropriate R reference number(s), in this case, the CAS Registry Numbers.
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? s r20 or r21
19364 RN=134523-00-5
1936 RN=134523-03-8
S1 19364 RN='134523-00-5' OR RN='134523-03-8' |
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5. SAVE a temporary SearchSave of the CAS Registry Numbers.
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? save temp lipitor
Temp SearchSave "LIPITOR" stored |
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6. BEGIN files 154, 55, 72.
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? b154,55,72
SYSTEM:OS - DIALOG OneSearch
File 154:MEDLINE(R) 1990-2012/Oct 26
(c) format only 2012 Dialog
File 55:Biosis Previews(R) 1993-2012/Oct W3
(c) 2012 The Thomson Corporation
File 72:EMBASE 1993-2012/Oct 29
(c) 2012 Elsevier B.V.
*File 72: Embase has been enhanced with Conference Abstract records.
Please see HELP NEWS072 for information.
Set Items Description
--- ----- ----------- |
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7. EXECUTE the temporary SearchSave. Dialog remembers the last SearchSave and executes it as long as you are in the same session. If you log off and on again, enter the SearchSave name or number after the EXS command.
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? exs
Executing LIPITOR
25138 RN=134523-00-5
19514 RN=134523-03-8
S1 25269 RN='134523-00-5' OR RN='134523-03-8' |
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8. SELECT drug names FROM MEDLINE to capture free-text terms from this file.
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? s (atorvastatin or lipitor) from 154
5375 ATORVASTATIN
127 LIPITOR
S2 5397 (ATORVASTATIN OR LIPITOR) FROM 154 |
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9. Combine the concepts from search Sets 1 and 2.
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? s s1 or s2
25269 S1
5397 S2
S3 30666 S1 OR S2 |
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10. Focus the search with keywords qualified to the Title (/TI) OR the Descriptor (/DE) fields.
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? s s3 and cholesterol/ti,de
30666 S3
349808 CHOLESTEROL/TI,DE
S4 11591 S3 AND CHOLESTEROL/TI,DE |
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11. LIMIT to articles published in the current year.
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? s s4/2012
11591 S4
2025665 PY=2012
S5 592 S4/2012 |
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12. REMOVE DUPLICATE records.
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? rd
S6 479 RD (unique items) |
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13. TYPE the first two records FROM EACH database in Format 6 to see titles and check for relevancy.
Note: some records omitted from the display.
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? t s6/6/1-2 from each
Dialog eLink: 
6/6/1 (Item 1 from file: 154)
DIALOG(R)File 154: MEDLINE(R)
(c) format only 2012 Dialog. All rights reserved.
43598704 PMID: 22551562
Relative efficacy of antilipemic agents in non-high-density lipoprotein
cholesterol reduction.
Aug 2012
Dialog eLink:
6/6/2 (Item 2 from file: 154)
DIALOG(R)File 154: MEDLINE(R)
(c) format only 2012 Dialog. All rights reserved.
43537671 PMID: 23050131
Improving Total-Cholesterol/HDL-Cholesterol Ratio Results in an Endothelial
Dysfunction Recovery in Peripheral Artery Disease Patients.
2012
Dialog eLink:
6/6/58 (Item 1 from file: 55)
DIALOG(R)File 55: Biosis Previews(R)
(c) 2012 The Thomson Corporation. All rights reserved.
0023394441 Biosis No.: 201200681270
Coenzyme Q(10) reverses mitochondrial dysfunction in atorvastatin-treated
mice and increases exercise endurance
2012
...
Dialog eLink:
6/6/140 (Item 1 from file: 72)
DIALOG(R)File 72: EMBASE
(c) 2012 Elsevier B.V. All rights reserved.
0088297959 EMBASE/MEDLINE No: 2012609518
Importance of assessing the effect of statins on the function of high-density
lipoproteins on coronary plaque
Publication Date: October 26, 2012
.... |
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14. TYPE selected records using Format 7 (Long), which displays bibliographic information and the abstract (if available). This is the first record From Embase.
The TYPE command specifies search set S4, format 7, record 1 FROM 72.
Note: Partial record shown.
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? t s6/7/1 from 72
Dialog eLink:  
6/7/140 (Item 1 from file: 72)
DIALOG(R)File 72: EMBASE
(c) 2012 Elsevier B.V. All rights reserved.
0088297959 EMBASE/MEDLINE No: 2012609518
Importance of assessing the effect of statins on the function of
high-density lipoproteins on coronary plaque
Kishida K.; Funahashi T.; Shimomura I.
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan; Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2-2 B-5, Yamada-oka, Suita, Osaka 565-0871, Japan
Author email: kkishida@imed2.med.osaka-u.ac.jp
Corresp. Author/Affil: Kishida K.: Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2-2 B-5, Yamada-oka, Suita, Osaka 565-0871, Japan
Corresp. Author Email: kkishida@imed2.med.osaka-u.ac.jp
Cardiovascular and Hematological Disorders - Drug Targets ( Cardiovasc. Hematol. Disord. Drug Targets ) ( Netherlands ) October 26, 2012 , 12/1 (28-34)
ISSN: 1871-529X
Item Identifier (DOI): 10.2174/187152912801823156
Document Type: Journal ; Article Record Type: Abstract
Language: English Summary language: English
Number of References: 56
High-density lipoproteins (HDL) are small particles comprised of phospholipids and stabilizing proteins, which carry cholesterol and triglycerides in the blood stream. The incidence of cardiovascular events is high in patients with low level of HDL-cholesterol (HDL-C). In the present study, we defined The PH index [Deltacoronary plaque volume/DeltaHDL-C] index as a putative clinical index of cholesterol efflux capacity of HDL from atheromatous plaque. The present study investigated the PH index in response to treatment with different types of HMG-CoA reductase inhibitors (statins), in contrast to similar changes in the PL index [Deltacoronary plaque volume/Deltalow-density lipoprotein-cholesterol (LDL-C)] by the same statins. Using the 2000-2011 PubMed database, the search keywords were "statins" and "intravascular ultrasound (IVUS)" and "plaque volume". Cross references were checked. PubMed search identified 29 references, and finally 4 .... |
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