1. BEGIN Files 154,72,55,34 to search major biomedical files.

2. SELECT the drug name(s). Use the (L) connector to search the drug name with Drug Interactions (IT) in EMBASE (File 72). The FROM command lets you specify a database to search.

Note: EMBASE has two-letter drug descriptors (e.g., IT) which can be linked to the drug name.

3. SELECT the drug name(s) and keyword for drug interactions limited to titles, descriptors and identifiers. Use FROM and the other three files.

SYSTEM:OS  - DIALOG OneSearch
  File 154:MEDLINE(R) 1990-2006/Aug 23
         (c) format only 2006 Dialog
  File  72:EMBASE 1993-2006/Aug 24
         (c) 2006 Elsevier B.V.
  File  55:Biosis Previews(R) 1993-2006/Aug W3
         (c) 2006 The Thomson Corporation
  File  34:SciSearch(R) Cited Ref Sci 1990-2006/Aug W3
         (c) 2006 The Thomson Corp
 
      Set  Items  Description
      ---  -----  -----------
?SELECT (REMICADE OR INFLIXIMAB)(L) IT FROM 72
               0  REMICADE/DE
            6188  INFLIXIMAB/DE
           72175  IT/DE
      S1      81  (REMICADE OR INFLIXIMAB)(L) IT FROM 72

?SELECT (REMICADE OR INFLIXIMAB) AND DRUG()INTERACT?/TI,DE,ID FROM 154, 55,34
>>>Term "ID" is not defined in one or more files
             486  REMICADE
            8925  INFLIXIMAB
         2907949  DRUG/TI,DE,ID
          601956  INTERACT?/TI,DE,ID
           56810  DRUG/TI,DE,ID(W)INTERACT?/TI,DE,ID
      S2      22  (REMICADE OR INFLIXIMAB) AND DRUG()INTERACT?/TI,DE,ID FROM 154,55,34

5. Remove duplicate records (RD) when searching more than one database.

?RD
      S4      97  RD  (unique items)

6. TYPE a couple of records FROM EACH database in Format 6 to see titles.

To select the appropriate record number, look at the range of records in the TYPE command (e.g., 4/6/14).

7. Choose the records you want to view and TYPE using Format 9 for the complete record.

The record chosen is record 14 from File 72.

Note: Part of this record is omitted from the display.

?T S4/9/14
 
  4/9/14     (Item 2 from file: 72)  
DIALOG(R)File  72:EMBASE
(c) 2006 Elsevier B.V. All rts. reserv.
 
13850937     EMBASE No: 2006262992
 Interstitial pneumonitis associated with infliximab therapy  
  Villeneuve E.; St-Pierre A.; Haraoui B.
  Dr. B. Haraoui, Department of Rheumatology, Centre Hospitalier de l'Universite de Montreal, Hopital Notre-Dame, 1560 Sherbrooke Est, Montreal, Que. H2L 4M1  Canada
  Journal of Rheumatology ( J. RHEUMATOL. ) (Canada)   2006, 33/6
  (1189-1193)
  CODEN: JRHUA   ISSN: 0315-162X
  DOCUMENT TYPE: Journal ; Article
  LANGUAGE: ENGLISH   SUMMARY LANGUAGE: ENGLISH
  NUMBER OF REFERENCES: 13
 
  Interstitial pneumonitis is a well documented, rare complication of methotrexate (MTX). We describe a patient with rheumatoid arthritis (RA) taking MTX for more than 3 years who then developed severe interstitial pneumonitis after a third infliximab infusion. Other similar cases are reviewed. Infliximab may potentiate pulmonary toxicity of MTX.
 
DRUG DESCRIPTORS:
*infliximab--adverse drug reaction--ae; *infliximab--drug dose--do; *infliximab--drug interaction--it; *methotrexate--adverse drug reaction--ae; *methotrexate--drug dose--do; *methotrexate--drug interaction--it; *methotrexate--drug therapy--dt; *methotrexate--oral drug administration--po prednisone--drug combination--cb; prednisone--drug dose--do; prednisone--drug therapy--dt; prednisone--oral drug administration--po; leflunomide--adverse drug reaction--ae; methylprednisolone; itraconazole--drug dose--do; oxygen; caspofungin